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Jaray Jaratjaroonphong. Design, synthesis and antibacterial activities of a series of bis(indolyl)arylmethanes. (). King Mongkut's University of Technology North Bangkok. Central Library. : , 2018.
Design, synthesis and antibacterial activities of a series of bis(indolyl)arylmethanes
Name: Chayamon Chantana
Organization :
Burapha University. Faculty of Science
Name: Onnicha Khaikate
Organization :
Burapha University. Faculty of Science
Name: Nannaphat Chumsri
Organization :
Burapha University. Faculty of Science
Name: Umaporn Thathaisong
Organization :
Burapha University. Faculty of Science
Name: Jaray Jaratjaroonphong
Organization :
Burapha University. Faculty of Science
Email :
jaray@buu.ac.th
keyword:
Bis(indolyl)methanes
LCSH:
Friedel-Crafts reaction
;
BIMs
Abstract:
3,3-Bis(indolyl)methanes (BIMs) are found in natural products and are known to
exhibit a broad range of biological activities. Although great success has been achieved in the
synthesis of BIMs, some of the reported methods suffer from disadvantages such as the use of
expensive and corrosive reagents, high catalyst loading and low yields of the products. In this
work, FeCl3.6H2O is shown to be an efficient catalyst for the Friedel-Crafts reaction of
aldehydes with a variety of indoles in methanol or acetonitrile under open-flask and mild
condition. In the presence of 15 mol% of FeCl3.6H2O at room temperature, the reaction
proceeds smoothly to afford some new 3,3'-bis(indoyl)arylmethane alkaloids in moderate to
excellent yields. Moreover, all the twelve BIMs synthesized showed promising antibacterial
activity against two Gram-positive bacteria namely, Staphylococcus aureus and Bacillus
subtilis. Structure-activity relationship analysis revealed that hydroxyaryl substituted BIMs
showed potent antibacterial activity. The 4-hydroxyphenyl linked 3,3'-bis(5-methoxy-1Hindol-
3-yl)methane 3k (R = 4-HOC6H4, R1 = 5-OMe) was found to exhibit the most potent
antibacterial activities against both S. aureus and B. subtilis. The development of synthetic
protocol will be useful for economical and ecofriendly synthesis of potent antibacterial BIM
class of compounds.
King Mongkut's University of Technology North Bangkok. Central Library
Address:
BANGKOK
Email:
library@kmutnb.ac.th
Created:
2018
Modified:
2019-07-22
Issued:
2019-07-12
บทความ/Article
application/pdf
BibliograpyCitation :
In Prince of Songkla University Faculty of Science. Pure and Applied Chemistry International Conference (PACCON 2018) (pp.OR87-OR91). Songkla : Prince of Songkla University
eng
©copyrights King Mongkut's University of Technology North Bangkok
RightsAccess:
ใช้เวลา
0.043563 วินาที
Chayamon Chantana
| Title | Contributor | Type |
|---|---|---|
| Design, synthesis and antibacterial activities of a series of bis(indolyl)arylmethanes
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Chayamon Chantana;Onnicha Khaikate;Nannaphat Chumsri;Umaporn Thathaisong;Jaray Jaratjaroonphong | บทความ/Article |
Onnicha Khaikate
| Title | Contributor | Type |
|---|---|---|
| Design, synthesis and antibacterial activities of a series of bis(indolyl)arylmethanes
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Chayamon Chantana;Onnicha Khaikate;Nannaphat Chumsri;Umaporn Thathaisong;Jaray Jaratjaroonphong | บทความ/Article |
Nannaphat Chumsri
| Title | Contributor | Type |
|---|---|---|
| Design, synthesis and antibacterial activities of a series of bis(indolyl)arylmethanes
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Chayamon Chantana;Onnicha Khaikate;Nannaphat Chumsri;Umaporn Thathaisong;Jaray Jaratjaroonphong | บทความ/Article |
Umaporn Thathaisong
| Title | Contributor | Type |
|---|---|---|
| Production of human ScFv that neutralizes influenza a virus infection
มหาวิทยาลัยธรรมศาสตร์ Umaporn Thathaisong, 1977- | Wanpen Chaicumpa Pramuan Tapchaisri Pongsri Tongtawe Potjanee Srimanote Thaweesak Songserm | วิทยานิพนธ์/Thesis |
| A study of genotypes of blastocysits hominis in Thailand
มหาวิทยาลัยมหิดล Umaporn Thathaisong | Peerapan Tan-ariya Saovanee Leelayoova Adisak Noonai | วิทยานิพนธ์/Thesis |
| Design, synthesis and antibacterial activities of a series of bis(indolyl)arylmethanes
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Chayamon Chantana;Onnicha Khaikate;Nannaphat Chumsri;Umaporn Thathaisong;Jaray Jaratjaroonphong | บทความ/Article |
Jaray Jaratjaroonphong