Bioactive compounds from dendrobium infundibulum

ÊÒ÷ÕèÁÕÄ·¸Ôì·Ò§ªÕÇÀÒ¾¨Ò¡àÍ×éͧµÒàËÔ¹

Name: Salinee Na Ranong

keyword: Bioactive compounds

; Dendrobium infundibulumÿ(Orchidaceae)

Abstract: Phytochemical study of the methanol extract from Dendrobium infundibulum (Orchidaceae) led to isolation of nine pure compounds including two new compounds (dendroinfundin A and dendroinfundin B) and seven known compounds (ephemeranthol A, moscatilin, aloifol I, batatasin III, 3,3'-dihydroxy-4,5-dimethoxybibenzyl, 3,4'-dihydroxy-3',4,5-trimethoxybibenzyl and dendrosinen B). Their structures were determined from their spectroscopic data. All compounds were then examined for their lipase and alpha-glucosidase inhibitory activities. Dendrosinen B (IC50 = 295.0±37.9 µM) showed moderate inhibitory activity against lipase when compared with orlistat (IC50 = 31.4±0.6 nM). Strong anti alpha-glucosidase agents were batatasin III (IC50 = 148.8±8.4 µM) and dendrosinen B (IC50 = 213.9±2.4 µM), which were more potent than acarbose (IC50 = 809.1±22.2 µM).

Abstract: ¡ÒÃÈÖ¡ÉÒ·Ò§¾Ä¡Éà¤ÁբͧÊÒÃÊ¡Ñ´àÁ·Ò¹ÍŢͧàÍ×éͧµÒàËÔ¹ (ǧÈì Orchidaceae) ÊÒÁÒöá¡ÊÒúÃÔÊØ·¸Ôìä´é 9 ª¹Ô´ ä´éá¡è ÊÒÃãËÁè 2 ª¹Ô´ (dendroinfundin A áÅÐ dendroinfundin B) áÅÐÊÒ÷Õèà¤ÂÁÕÃÒ§ҹÁÒ¡è͹ 7 ª¹Ô´ (ephemeranthol A, moscatilin, aloifol I, batatasin III, 3,3'-dihydroxy-4,5-dimethoxybibenzyl, 3,4'-dihydroxy-3',4,5-trimethoxybibenzyl áÅÐ dendrosinen B) ¾ÔÊÙ¨¹ìâ¤Ã§ÊÃéÒ§ÊÒÃâ´ÂÍÒÈÑ¢éÍÁÙÅ·Ò§Ê໡â·ÃÊâ¡»Õ ÊÒ÷Ñé§ËÁ´¶Ù¡¹ÓÁÒ·´Êͺķ¸Ôì㹡ÒÃÂѺÂÑé§à͹ä«ÁìäÅà»ÊáÅÐà͹ä«ÁìáÍÅ¿Ò-¡ÅÙ⤫Ôà´Ê ¾ºÇèÒ ÊÒ÷ÕèÁÕÄ·¸ÔìÂѺÂÑé§à͹ä«ÁìäÅà»Êä´éÍÂèÒ§Íè͹ ¤×Í dendrosinen B (IC50 = 295.0±37.9 µM) «Öè§ÁÕÄ·¸ÔìÂѧäÁè´ÕàÁ×èÍà·Õº¡Ñº orlistat (IC50 = 31.4±0.6 nM) áÅÐÊÒ÷ÕèÁÕÄ·¸ÔìÂѺÂÑé§à͹ä«ÁìáÍÅ¿Ò¡ÅÙ⤫Ôà´Êä´é´Õ ä´éá¡è batatasin III (IC50 = 148.8±8.4 µM) áÅÐ dendrosinen B (IC50 = 213.9±2.4 µM) «Öè§ÁÕÄ·¸Ôì·Õèáç¡ÇèÒ acarbose (IC50 = 809.1±22.2 µM)

Chulalongkorn University. Office of Academic Resources

Address: BANGKOK

Email: cuir@car.chula.ac.th

Name: Boonchoo Sritularak

Role: advisor

Name: Kittisak Likhitwitayawuid

Role: advisor

Created: 2017

Modified: 2020-07-16

Issued: 2020-07-16

ÇÔ·ÂÒ¹Ô¾¹¸ì/Thesis

application/pdf

URL: http://cuir.car.chula.ac.th/handle/123456789/60891

eng

DegreeName: Master of Science in Pharmacy

Level: Master's Degree

Descipline: Pharmacognosy

Grantor: Chulalongkorn University

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